Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi

Molecular mechanisms underlying the reciprocal regulation of the two major surface lipoproteins and virulence factors of Borrelia burgdorferi, OspA and OspC, are not fully understood. Herein, we report that inactivation of the ospAB operon resulted in overproduction of OspC and many other lipoprotei...

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Veröffentlicht in:	Molecular microbiology 2008-12, Vol.70 (6), p.1453-1464
Hauptverfasser:	He, Ming, Oman, Tara, Xu, Haijun, Blevins, Jon, Norgard, Michael V, Yang, X. Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Bacterial - biosynthesis Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Antigens, Surface - genetics Antigens, Surface - metabolism Bacteria Bacterial Outer Membrane Proteins - biosynthesis Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Bacterial Proteins - metabolism Bacterial Vaccines - genetics Bacterial Vaccines - metabolism Bacteriology Biological and medical sciences Borrelia burgdorferi Borrelia burgdorferi - genetics Borrelia burgdorferi - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Ixodidae Lipoproteins - genetics Lipoproteins - metabolism Microbiology Miscellaneous Molecules Mutation Operon Sigma Factor - metabolism Signal transduction Virology Virulence Factors - genetics Virulence Factors - metabolism
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