Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

Microbial nucleic acids are critical for the induction of innate immune responses, a host defense mechanism against infection by microbes. Recent studies have indicated that double-stranded DNA (dsDNA) induces potent innate immune responses via the induction of type I IFN (IFN) and IFN-inducible gen...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-12, Vol.106 (49), p.20842-20846
Hauptverfasser:	Saitoh, Tatsuya, Fujita, Naonobu, Hayashi, Takuya, Takahara, Keigo, Satoh, Takashi, Lee, Hanna, Matsunaga, Kohichi, Kageyama, Shun, Omori, Hiroko, Noda, Takeshi, Yamamoto, Naoki, Kawai, Taro, Ishii, Ken, Takeuchi, Osamu, Yoshimori, Tamotsu, Akira, Shizuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antivirals Autophagy - drug effects Autophagy-Related Proteins Biological Sciences Cell Membrane - drug effects Cell Membrane - metabolism Cell Membrane - ultrastructure Deoxyribonucleic acid DNA DNA - pharmacology Embryo, Mammalian - cytology Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - ultrastructure Gene expression regulation Genes Golgi apparatus Immunity, Innate - drug effects Innate immunity Kinases Membrane Proteins - metabolism Membranes Mice Microorganisms Microscopy Physiological regulation Protein Transport - drug effects Protein-Serine-Threonine Kinases - metabolism Proteins RNA Signal transduction Vesicular Transport Proteins
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