Genetic Ablation of Calcium-independent Phospholipase A2γ Leads to Alterations in Hippocampal Cardiolipin Content and Molecular Species Distribution, Mitochondrial Degeneration, Autophagy, and Cognitive Dysfunction

Genetic ablation of calcium-independent phospholipase A2γ (iPLA2γ) results in profound alterations in hippocampal phospholipid metabolism and mitochondrial phospholipid homeostasis resulting in enlarged and degenerating mitochondria leading to autophagy and cognitive dysfunction. Shotgun lipidomics...

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Veröffentlicht in:	The Journal of biological chemistry 2009-12, Vol.284 (51), p.35632-35644
Hauptverfasser:	Mancuso, David J., Kotzbauer, Paul, Wozniak, David F., Sims, Harold F., Jenkins, Christopher M., Guan, Shaoping, Han, Xianlin, Yang, Kui, Sun, Gang, Malik, Ibrahim, Conyers, Sara, Green, Karen G., Schmidt, Robert E., Gross, Richard W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Metabolism and Bioenergetics
Online-Zugang:	Volltext
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