High Expression of the PAX3-FKHR Oncoprotein Is Required to Promote Tumorigenesis of Human Myoblasts

PAX3-FKHR is a fusion oncoprotein generated by the 2;13 chromosomal translocation in alveolar rhabdomyosarcoma (ARMS), a cancer associated with the skeletal muscle lineage. Previous studies determined that high-level PAX3-FKHR expression is a consistent feature in ARMS tumors. To investigate the rel...

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Veröffentlicht in:	The American journal of pathology 2009-12, Vol.175 (6), p.2600-2608
Hauptverfasser:	Xia, Shujuan J, Holder, Dara D, Pawel, Bruce R, Zhang, Chune, Barr, Frederic G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Southern Blotting, Western Cell Transformation, Neoplastic - genetics Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Mice, SCID Myoblasts - metabolism Myoblasts - pathology N-Myc Proto-Oncogene Protein Nuclear Proteins - genetics Oncogene Proteins - genetics Oncogene Proteins, Fusion - biosynthesis Oncogene Proteins, Fusion - genetics Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Regular Reverse Transcriptase Polymerase Chain Reaction Rhabdomyosarcoma, Alveolar - genetics Rhabdomyosarcoma, Alveolar - metabolism Transduction, Genetic Xenograft Model Antitumor Assays
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