Robust Th1 and Th17 Immunity Supports Pulmonary Clearance but Cannot Prevent Systemic Dissemination of Highly Virulent Cryptococcus neoformans H99

The present study dissected the role of a Th2 bias in pathogenesis of Cryptococcus neoformans H99 infection by comparing inhalational H99 infections in wild-type BALB/c and IL-4/IL-13 double knockout mice. H99-infected wild-type mice showed all major hallmarks of Th2 but not Th1/Th17 immunity in the...

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Veröffentlicht in:	The American journal of pathology 2009-12, Vol.175 (6), p.2489-2500
Hauptverfasser:	Zhang, Yanmei, Wang, Fuyuan, Tompkins, Kristin C, McNamara, Andrew, Jain, Aditya V, Moore, Bethany B, Toews, Galen B, Huffnagle, Gary B, Olszewski, Michal A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chemotaxis, Leukocyte Cryptococcosis - immunology Cryptococcosis - pathology Cryptococcus neoformans Cryptococcus neoformans - immunology Cryptococcus neoformans - pathogenicity Disease Progression Interleukin-13 - deficiency Interleukin-13 - genetics Interleukin-13 - immunology Interleukin-17 - immunology Interleukin-4 - deficiency Interleukin-4 - genetics Interleukin-4 - immunology Investigative techniques, diagnostic techniques (general aspects) Macrophage Activation - immunology Medical sciences Mice Mice, Inbred BALB C Mice, Knockout Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Regular Reverse Transcriptase Polymerase Chain Reaction T-Lymphocyte Subsets - immunology Th1 Cells - immunology Th2 Cells - immunology Virulence
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