IL-10 promotes neuronal survival following spinal cord injury

We have previously reported that the anti-inflammatory cytokine IL-10 induces a number of signaling cascades through the IL-10 receptor in spinal cord neurons in vitro to activate NF-κB transcription Bcl-2 and Bcl-x L and that, after exposure to glutamate IL-10, blocks cytochrome c release and caspa...

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Veröffentlicht in:	Experimental neurology 2009-11, Vol.220 (1), p.183-190
Hauptverfasser:	Zhou, Zhigang, Peng, Xiangmin, Insolera, Ryan, Fink, David J., Mata, Marina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - metabolism Apoptosis Apoptosis Regulatory Proteins - metabolism Biological and medical sciences Cell Survival - genetics Cells, Cultured Cytokine Disease Models, Animal Female Gene therapy Genetic Therapy - methods Genetic Vectors - pharmacology Genetic Vectors - therapeutic use Herpes simplex virus Injuries of the nervous system and the skull. Diseases due to physical agents Interleukin-10 Interleukin-10 - genetics Interleukin-10 - metabolism Medical sciences Nerve Degeneration - etiology Nerve Degeneration - physiopathology Nerve Degeneration - prevention & control Neurology Rats Rats, Sprague-Dawley Receptors, Interleukin-10 - genetics Receptors, Interleukin-10 - metabolism Signal Transduction - genetics Signal Transduction - immunology Simplexvirus - genetics Spinal Cord - immunology Spinal Cord - metabolism Spinal Cord Injuries - genetics Spinal Cord Injuries - immunology Spinal Cord Injuries - therapy Spinal cord injury Transfection - methods Traumas. Diseases due to physical agents Treatment Outcome
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