Dicer1 functions as a haploinsufficient tumor suppressor

While the global down-regulation of microRNAs (miRNAs) is a common feature of human tumors, its genetic basis is largely undefined. To explore this question, we analyzed the consequences of conditional Dicer1 mutation (Dicer1 "floxed" or Dicer1(fl)) on several mouse models of cancer. Here...

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Veröffentlicht in:	Genes & development 2009-12, Vol.23 (23), p.2700-2704
Hauptverfasser:	Kumar, Madhu S, Pester, Ryan E, Chen, Cindy Y, Lane, Keara, Chin, Christine, Lu, Jun, Kirsch, David G, Golub, Todd R, Jacks, Tyler
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Disease Models, Animal Gene Deletion Humans Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - physiopathology Mice Mice, Inbred C57BL MicroRNAs - metabolism Mutation - genetics Research Communication Ribonuclease III - genetics Ribonuclease III - metabolism Sarcoma - genetics Sarcoma - mortality Sarcoma - physiopathology Survival Analysis Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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