Nodal Diffuse Large B-cell Lymphomas in Children and Adolescents: Immunohistochemical Expression Patterns and c-MYC Translocation in Relation to Clinical Outcome

Diffuse large B-cell lymphoma (DLBCL) is a very infrequent neoplasm in the pediatric age group; therefore there are very few studies on the immunophenotype or genetics of these cases. We studied a series of 16 patients with nodal DLBCL occurring in patients between 10 and 18 years of age. The cases...

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Veröffentlicht in:	The American journal of surgical pathology 2009-12, Vol.33 (12), p.1815-1822
Hauptverfasser:	GUALCO, Gabriela, WEISS, Lawrence M, HARRINGTON, William J, BACCHI, Carlos E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Child Chromosome aberrations Disease-Free Survival DNA-Binding Proteins - analysis Female Gene Expression Regulation, Neoplastic Hematologic and hematopoietic diseases Humans Immunohistochemistry In Situ Hybridization, Fluorescence Interferon Regulatory Factors - analysis Investigative techniques, diagnostic techniques (general aspects) Kaplan-Meier Estimate Ki-67 Antigen - analysis Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Large B-Cell, Diffuse - chemistry Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - mortality Lymphoma, Large B-Cell, Diffuse - pathology Lymphoma, Large B-Cell, Diffuse - therapy Male Medical genetics Medical sciences Neprilysin - analysis Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Predictive Value of Tests Proportional Hazards Models Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins c-bcl-2 - analysis Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-6 Proto-Oncogene Proteins c-myc - genetics Retrospective Studies Risk Assessment Time Factors Translocation, Genetic Treatment Outcome
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