Molecular Evolution of Adeno-associated Virus for Enhanced Glial Gene Delivery

The natural tropism of most viral vectors, including adeno-associated viral (AAV) vectors, leads to predominant transduction of neurons and epithelia within the central nervous system (CNS) and retina. Despite the clinical relevance of glia for homeostasis in neural tissue, and as causal contributor...

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Veröffentlicht in:	Molecular therapy 2009-12, Vol.17 (12), p.2088-2095
Hauptverfasser:	Koerber, James T, Klimczak, Ryan, Jang, Jae-Hyung, Dalkara, Deniz, Flannery, John G, Schaffer, David V
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Animals Astrocytes - metabolism Bioengineering Bioinformatics Cells, Cultured Chemical engineering Cytomegalovirus Dependovirus - genetics Dependovirus - growth & development Directed Molecular Evolution Drug Delivery Systems Evolution Gene Transfer Techniques Genetic engineering Genetic Vectors Genomes Glioblastoma - genetics Glioblastoma - metabolism Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Heparan sulfate Homeostasis Humans Mutagenesis Nervous system Neuroblastoma - genetics Neuroblastoma - metabolism Neurosciences Original Peptides Rats Rats, Sprague-Dawley Retina Serotyping Success Transduction, Genetic Vectors (Biology) Viral infections Viruses
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