A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo

Abstract Severe acute respiratory syndrome (SARS) is a highly lethal emerging disease caused by coronavirus SARS-CoV. New lethal animal models for SARS were needed to facilitate antiviral research. We adapted and characterized a new strain of SARS-CoV (strain v2163) that was highly lethal in 5- to 6...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2009-12, Vol.395 (2), p.210-222
Hauptverfasser:	Day, Craig W, Baric, Ralph, Cai, Sui Xiong, Frieman, Matt, Kumaki, Yohichi, Morrey, John D, Smee, Donald F, Barnard, Dale L
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampligen Animals Antiviral Agents - pharmacology Chemokine Cytokine Cytokines - metabolism Female Gene Expression Regulation - physiology Genome, Viral IL-6 Infectious Disease Lethal Lung - metabolism Lung - pathology Mice Mice, Inbred BALB C Mouse Mutation Protease inhibitor Ribavirin SARS coronavirus SARS-CoV Severe Acute Respiratory Syndrome - drug therapy Severe Acute Respiratory Syndrome - metabolism Severe Acute Respiratory Syndrome - virology Severe acute respiratory syndrome-related coronavirus - physiology UDA Viral Proteins - genetics Viral Proteins - metabolism
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