Neurochemical, behavioral and architectural changes after chronic inactivation of NMDA receptors in mice

Schizophrenia is a psychotic illness characterized by problems in perception, learning, and memory. Post-mortem clinical data revealed abnormalities in neuronal organization, reduced soma and dendritic tree size. In rodents, reduction of glutamatergic neurotransmission by NMDA receptor antagonists m...

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Veröffentlicht in:	Neuroscience letters 2010-01, Vol.468 (2), p.166-171
Hauptverfasser:	Elhardt, Mary, Martinez, Luis, Tejada-Simon, Maria Victoria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Animals, Newborn Behavior, Animal Biological and medical sciences Conditioning (Psychology) Disease Models, Animal Dizocilpine Maleate Fundamental and applied biological sciences. Psychology Hippocampus - metabolism Hippocampus - pathology Hippocampus - physiopathology Learning Medical sciences Memory Mice Mice, Inbred C57BL MK-801 Neuronal Plasticity Neurons - pathology NMDA receptor hypofunction Protein Biosynthesis Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Schizophrenia Schizophrenia - chemically induced Schizophrenia - metabolism Schizophrenia - pathology Schizophrenic Psychology Time Factors Vertebrates: nervous system and sense organs
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