Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells

PURPOSE Hsp90 is important in the folding, maturation and stabilization of pro‐tumorigenic client proteins and represents a viable drug target for the design of chemotherapies. Previously, we reported the development of novobiocin analogues designed to inhibit the C‐terminal portion of Hsp90, which...

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