Low Micromolar Zinc Accelerates the Fibrillization of Human Tau via Bridging of Cys-291 and Cys-322

A hallmark of a group of neurodegenerative diseases such as Alzheimer disease is the formation of neurofibrillary tangles, which are principally composed of bundles of filaments formed by microtubule-associated protein Tau. Clarifying how natively unstructured Tau protein forms abnormal aggregates i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2009-12, Vol.284 (50), p.34648-34657
Hauptverfasser:	Mo, Zhong-Ying, Zhu, Ying-Zhu, Zhu, Hai-Li, Fan, Jun-Bao, Chen, Jie, Liang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Cysteine - metabolism Disulfides - metabolism Humans Microscopy, Atomic Force Molecular Sequence Data Neurofibrillary Tangles - chemistry Neurofibrillary Tangles - metabolism Neurofibrillary Tangles - pathology Oxidation-Reduction Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Protein Binding Protein Conformation Protein Folding Protein Structure and Folding Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism tau Proteins - chemistry tau Proteins - genetics tau Proteins - metabolism Thermodynamics Zinc - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!