Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expression

Cutaneous wounds heal more slowly in elderly males than in elderly females, suggesting a role for sex hormones in the healing process. Indeed, androgen/androgen receptor (AR) signaling has been shown to inhibit cutaneous wound healing. AR is expressed in several cell types in healing skin, including...

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Veröffentlicht in:	The Journal of clinical investigation 2009-12, Vol.119 (12), p.3739-3751
Hauptverfasser:	Lai, Jiann-Jyh, Lai, Kuo-Pao, Chuang, Kuang-Hsiang, Chang, Philip, Yu, I-Chen, Lin, Wen-Jye, Chang, Chawnshang
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Aged Analysis Androgen Receptor Antagonists Androgens Animals Curcumin - administration & dosage Curcumin - analogs & derivatives Female Health aspects Hormones Humans Macrophages Macrophages - immunology Macrophages - physiology Male Mice Mice, Inbred C57BL Mice, Knockout Models, Biological Receptors, Androgen - deficiency Receptors, Androgen - genetics Receptors, Androgen - physiology Sex Characteristics Skin - drug effects Skin - immunology Skin - injuries Skin - physiopathology Testosterone - blood Tumor necrosis factor Tumor Necrosis Factor-alpha - biosynthesis Wound healing Wound Healing - drug effects Wound Healing - genetics Wound Healing - immunology Wound Healing - physiology
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