Molecular, Antigenic, and Functional Characteristics of Ferric Enterobactin Receptor CfrA in Campylobacter jejuni

The ferric enterobactin receptor CfrA not only is responsible for high-affinity iron acquisition in Campylobacter jejuni but also is essential for C. jejuni colonization in animal intestines. In this study, we determined the feasibility of targeting the iron-regulated outer membrane protein CfrA for...

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Veröffentlicht in:	Infection and Immunity 2009-12, Vol.77 (12), p.5437-5448
Hauptverfasser:	Zeng, Ximin, Xu, Fuzhou, Lin, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid substitution Animals Antibodies, Bacterial - blood Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Bacterial Outer Membrane Proteins - metabolism Bacterial Proteins - genetics Bacterial Proteins - immunology Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Blotting, Western - methods Campylobacter Campylobacter Infections - immunology Campylobacter Infections - veterinary Campylobacter jejuni Campylobacter jejuni - genetics Campylobacter jejuni - metabolism Campylobacter jejuni - physiology Carrier Proteins - genetics Carrier Proteins - immunology Carrier Proteins - metabolism Chickens Colonization Complementation DNA, Bacterial - chemistry DNA, Bacterial - genetics Enterobactin Ferric enterobactin Fundamental and applied biological sciences. Psychology Gene Expression Profiling Gene Knockout Techniques Genetic Complementation Test Hormones Hydroxamic Acids - metabolism Immunoblotting Immunogenicity Immunoglobulin G Infection Intestine Iron Microbiology Miscellaneous Molecular Pathogenesis Molecular Sequence Data Mutagenesis Mutagenesis, Site-Directed outer membrane proteins Polymerase chain reaction Polymerase Chain Reaction - methods Poultry Diseases - immunology Poultry Diseases - microbiology Primers Protein Binding Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Sequence Analysis, DNA Sequence Homology, Amino Acid Stress Vaccines Virulence Factors - genetics Virulence Factors - immunology Virulence Factors - metabolism
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