Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Rapamycin for a longer life? The antitumour drug rapamycin targets TOR, a kinase that is part of the PI3K–AKT–mTOR cascade, involved in regulating protein translation, cell growth and autophagy. Reducing TOR function is known to extend the life of yeast, worms and flies. Now experiments replicated i...

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Veröffentlicht in:	Nature (London) 2009-07, Vol.460 (7253), p.392-395
Hauptverfasser:	Harrison, David E., Strong, Randy, Sharp, Zelton Dave, Nelson, James F., Astle, Clinton M., Flurkey, Kevin, Nadon, Nancy L., Wilkinson, J. Erby, Frenkel, Krystyna, Carter, Christy S., Pahor, Marco, Javors, Martin A., Fernandez, Elizabeth, Miller, Richard A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Age Aging - drug effects Aging - genetics Aging - physiology Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Carrier Proteins - antagonists & inhibitors Carrier Proteins - metabolism Cellular signal transduction Diet Dietary supplements Disease Susceptibility Female Females Genetic aspects Humanities and Social Sciences letter Life expectancy Life span Life spans (Biology) Longevity - drug effects Longevity - genetics Longevity - physiology Male Males Mammals Medical sciences Mice Mortality multidisciplinary Nematoda Pharmacology. Drug treatments Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Phosphotransferases (Alcohol Group Acceptor) - metabolism Physiological aspects Rapamycin Rodents Science Science (multidisciplinary) Sirolimus - administration & dosage Sirolimus - pharmacology Specific Pathogen-Free Organisms Survival Analysis Time Factors TOR Serine-Threonine Kinases Transgenic animals Yeasts
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