Chronic Administration of KB-R7943 Induces Up-regulation of Cardiac NCX1

The NCX1 (sodium-calcium exchanger) is up-regulated in human heart failure and in many animal models of heart failure. The potential benefits and risks of therapeutically blocking NCX1 in heart failure and during ischemia-reperfusion are being actively investigated. In this study, we demonstrate tha...

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Veröffentlicht in:	The Journal of biological chemistry 2009-10, Vol.284 (40), p.27265-27272
Hauptverfasser:	Xu, Lin, Kappler, Christiana S., Mani, Santhosh K., Shepherd, Neal R., Renaud, Ludivine, Snider, Paige, Conway, Simon J., Menick, Donald R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - administration & dosage Adrenergic beta-Antagonists - pharmacology Animals Anti-Arrhythmia Agents - administration & dosage Anti-Arrhythmia Agents - pharmacology Calcium Channel Blockers - administration & dosage Calcium Channel Blockers - pharmacology Calcium Channels, L-Type - metabolism Cats Enzyme Activation - drug effects Heart - drug effects Membrane Transport, Structure, Function, and Biogenesis Mice Myocardium - metabolism Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Receptors, Adrenergic, beta - metabolism Sodium-Calcium Exchanger - genetics Sodium-Calcium Exchanger - metabolism Sodium-Hydrogen Exchangers - antagonists & inhibitors Thiourea - administration & dosage Thiourea - analogs & derivatives Thiourea - pharmacology Time Factors Up-Regulation - drug effects
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