Identification of GAS1 as an Epirubicin Resistance-related Gene in Human Gastric Cancer Cells with a Partially Randomized Small Interfering RNA Library

Epirubicin has been widely used for chemotherapeutic treatment of gastric cancer; however, intrinsic and acquired chemoresistance remains an obstacle to successful management. The mechanisms underlying epirubicin resistance are still not well defined. Here we report the construction and application...

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Veröffentlicht in:	The Journal of biological chemistry 2009-09, Vol.284 (39), p.26273-26285
Hauptverfasser:	Zhao, Lina, Pan, Yanglin, Gang, Yi, Wang, Honghong, Jin, Haifeng, Tie, Jun, Xia, Lin, Zhang, Yongguo, He, Lijie, Yao, Liping, Qiao, Taidong, Li, Tingting, Liu, Zhiguo, Fan, Daiming
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Antibiotics, Antineoplastic - pharmacology Apoptosis Apoptosis - drug effects ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters ATP-binding protein Base Sequence Bax protein Bcl-2 protein bcl-2-Associated X Protein - metabolism Blotting, Western Breast cancer Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Survival - drug effects Chemoresistance Cisplatin Cisplatin - pharmacology Colonies Drug dependence Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - genetics Epirubicin Epirubicin - pharmacology Flow Cytometry Fluorouracil - pharmacology Gas1 protein Gastric cancer Gene Library GPI-Linked Proteins Humans Membrane Proteins - genetics Membrane Proteins - metabolism Molecular Sequence Data MRP1 protein Multidrug resistance Neoplasm Proteins P-Glycoprotein Proto-Oncogene Proteins c-bcl-2 - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN protein Retrovirus Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering - genetics RNA-Mediated Regulation and Noncoding RNAs siRNA Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Transfection Tumor cell lines Verapamil
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