Evidence That Nucleosomes Inhibit Mismatch Repair in Eukaryotic Cells

The influence of chromatin structure on DNA metabolic processes, including DNA replication and repair, has been a matter of intensive studies in recent years. Although the human mismatch repair (MMR) reaction has been reconstituted using purified proteins, the influence of chromatin structure on hum...

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Veröffentlicht in:	The Journal of biological chemistry 2009-11, Vol.284 (48), p.33056-33061
Hauptverfasser:	Li, Feng, Tian, Lei, Gu, Liya, Li, Guo-Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - metabolism Adenosine Triphosphate - metabolism Base Sequence DNA Mismatch Repair DNA: , Repair, Recombination, and Chromosome Dynamics Electrophoresis, Agar Gel Electrophoresis, Polyacrylamide Gel Electrophoretic Mobility Shift Assay Eukaryotic Cells - metabolism Histones - genetics Histones - metabolism Humans MutS DNA Mismatch-Binding Protein - metabolism Nucleic Acid Heteroduplexes - genetics Nucleic Acid Heteroduplexes - metabolism Nucleosomes - metabolism Oligonucleotides - genetics Oligonucleotides - metabolism Protein Binding
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