NADPH oxidases are responsible for the failure of nitric oxide to inhibit migration of smooth muscle cells exposed to high glucose

Our previous studies showed that nitric oxide (NO) fails to inhibit migration of smooth muscle cells (SMC) exposed to high glucose (HG) because of oxidation of the most reactive cysteine, cysteine-674, on the sarco/endoplasmic reticulum ATPase, preventing its S-glutathiolation, thus blocking NO acti...

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Veröffentlicht in:	Free radical biology & medicine 2009-12, Vol.47 (11), p.1578-1583
Hauptverfasser:	Tong, XiaoYong, Schröder, Katrin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aorta, Thoracic - cytology Cell Movement Cloning, Molecular Free radicals Glucose - metabolism High glucose Migration Mutation Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - metabolism NADH, NADPH Oxidoreductases - genetics NADH, NADPH Oxidoreductases - metabolism NADPH oxidase NADPH Oxidase 1 NADPH Oxidase 4 NADPH Oxidases - genetics NADPH Oxidases - metabolism Nitric oxide Nitric Oxide - metabolism rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Reactive oxygen species RNA, Small Interfering - genetics
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