Ultrasound triggered cell death in vitro with doxorubicin loaded poly lactic-acid contrast agents

Traditional chemotherapy generally results in systemic toxicity, which also limits drug levels at the area of need. Two ultrasound contrast agents (UCA), with diameters between 1–2 μm in diameter and shell thicknesses of 100–200 nm, composed of poly lactic-acid (PLA), one loaded by surface adsorptio...

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Veröffentlicht in:	Ultrasonics 2009-12, Vol.49 (8), p.628-633
Hauptverfasser:	Eisenbrey, J.R., Huang, P., Hsu, J., Wheatley, M.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Breast Neoplasms - pathology Breast Neoplasms - physiopathology Cardiovascular system Cell Line, Tumor Chemotherapy Contrast Media - chemistry Contrast Media - radiation effects Contrast Media - therapeutic use Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemistry Delayed-Action Preparations - radiation effects Dose-Response Relationship, Radiation Doxorubicin Doxorubicin - administration & dosage Doxorubicin - chemistry Drug delivery Electroporation - methods Humans Investigative techniques, diagnostic techniques (general aspects) Lactic Acid - chemistry Lactic Acid - radiation effects Medical sciences Pharmacology. Drug treatments Poly lactic-acid Polyesters Polymers - chemistry Polymers - radiation effects Radiation Dosage Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Sonication - methods Technology. Biomaterials. Equipments. Material. Instrumentation Ultrasonic investigative techniques Ultrasound contrast agents
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