Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1

Type II diabetes mellitus (T2DM) is often accompanied by non-alcoholic steatohepatitis (NASH) and associated with hypercholesterolemia, that is, increased levels of plasma low-density lipoprotein (LDL) and oxidized LDL (ox-LDL). Approximately one-third of NASH develops hepatic fibrosis. The role of...

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Veröffentlicht in:	Laboratory investigation 2009-11, Vol.89 (11), p.1275-1290
Hauptverfasser:	Kang, Qiaohua, Chen, Anping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Blotting, Western Coloring Agents - pharmacology Curcumin - pharmacology diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation - drug effects Gene Silencing hepatic fibrosis hepatic stellate cell Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism hypercholesterolemia Hypercholesterolemia - complications Hypercholesterolemia - metabolism Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Lipoproteins, LDL - genetics Lipoproteins, LDL - metabolism Liver Cirrhosis - complications Liver Cirrhosis - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Medicine Medicine & Public Health Mutagenesis, Site-Directed Other diseases. Semiology Pathology phytochemical PPAR gamma - drug effects PPAR gamma - metabolism Rats Rats, Sprague-Dawley Receptors, Oxidized LDL - genetics research-article
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