Kidney-derived mesenchymal stem cells contribute to vasculogenesis, angiogenesis and endothelial repair

We isolated a clonal cell line (4E) from kidneys of mice expressing green fluorescent protein controlled by the endothelial-specific Tie2 promoter. When grown in a three-dimensional matrigel matrix they formed a fluorescent capillary network. In vivo angiogenesis assays using growth factor-depleted...

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Veröffentlicht in:	Kidney international 2008-10, Vol.74 (7), p.879-889
Hauptverfasser:	Chen, Jun, Park, Hyeong-Cheon, Addabbo, Francesco, Ni, Jie, Pelger, Edward, Li, Houwei, Plotkin, Matthew, Goligorsky, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute ischemic renal injury angiogenesis Animals Cell Culture Techniques Cell Differentiation Clone Cells Coculture Techniques Endothelial Cells - cytology Endothelial Cells - physiology Graft Survival Green Fluorescent Proteins - genetics Ischemia Kidney - cytology Kidney - pathology Kidney - physiology Kidney Diseases - pathology Kidney Diseases - therapy Kidney Tubules - physiology Mesenchymal Stem Cell Transplantation - methods mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mice Mice, Transgenic Myocytes, Smooth Muscle - cytology Neovascularization, Physiologic Regeneration Vascular Endothelial Growth Factor A - analysis Vascular Endothelial Growth Factor A - pharmacology vasculogenesis
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