Osteoclast inhibitory peptide-1 (OIP-1) inhibits measles virus nucleocapsid protein stimulated osteoclast formation/activity

Paget's disease (PD) of bone is characterized by increased activity of large abnormal osteoclasts (OCLs) which contain paramyxoviral nuclear and cytoplasmic inclusions. MVNP gene expression has been shown to induce pagetic phenotype in OCLs. We previously characterized the osteoclast inhibitory...

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Veröffentlicht in:	Journal of cellular biochemistry 2008-07, Vol.104 (4), p.1500-1508
Hauptverfasser:	Shanmugarajan, Srinivasan, Youssef, Rimon F., Pati, Parmita, Ries, William L., Rao, D. Sudhaker, Reddy, Sakamuri V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - pharmacology Animals ATPases Associated with Diverse Cellular Activities Bone Resorption - drug therapy Cell Differentiation - drug effects Gene Expression Regulation - drug effects Humans Leukocytes, Mononuclear - pathology LIM Domain Proteins Measles virus measles virus nucleocapsid Mice Mice, Transgenic Nucleocapsid Proteins - genetics Nucleocapsid Proteins - pharmacology OIP-1 Osteitis Deformans - pathology osteoclast Osteoclasts - drug effects Osteoclasts - pathology Paget's disease of bone Proteasome Endopeptidase Complex RANK ligand RANK Ligand - pharmacology TNF Receptor-Associated Factor 2 - genetics Transcription Factors - pharmacology Transduction, Genetic
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