Mutations in mitochondrial DNA polymerase-γ promote breast tumorigenesis

Decreased mitochondrial oxidative phosphorylation (OXPHOS) is one of the hallmarks of cancer. To date, the identity of nuclear gene(s) responsible for decreased OXPHOS in tumors remains unknown. It is also unclear whether mutations in nuclear gene(s) responsible for decreased OXPHOS affect tumorigen...

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Veröffentlicht in:	Journal of human genetics 2009-09, Vol.54 (9), p.516-524
Hauptverfasser:	Singh, Keshav K, Ayyasamy, Vanniarajan, Owens, Kjerstin M, Koul, Manika Sapru, Vujcic, Marija
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Deoxyribonucleic acid DNA DNA polymerase DNA Polymerase gamma DNA, Mitochondrial - genetics DNA-directed DNA polymerase DNA-Directed DNA Polymerase - genetics Exons Exonuclease Female Gene Expression Gene Function Gene Therapy Genome, Mitochondrial Human Genetics Humans Invasive species Membrane potential Mitochondria - enzymology Mitochondria - genetics Mitochondrial DNA Molecular Medicine Mutagenesis, Site-Directed Mutation Mutation - genetics Neoplasm Invasiveness original-article Oxidative phosphorylation Phosphorylation Plasmids Point mutation Reactive oxygen species Splice junctions Tumor Cells, Cultured Tumorigenesis Tumorigenicity Tumors
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