Unusual Water-mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18

The unique cytokine interleukin-18 (IL-18) acts synergistically with IL-12 to regulate T-helper 1 and 2 lymphocytes and, as such, seems to underlie the pathogenesis of various autoimmune and allergic diseases. Several anti-IL-18 agents are in clinical development, including the recombinant human ant...

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Veröffentlicht in:	The Journal of biological chemistry 2009-09, Vol.284 (36), p.24478-24489
Hauptverfasser:	Argiriadi, Maria A., Xiang, Tao, Wu, Chengbin, Ghayur, Tariq, Borhani, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ANTIBODIES Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antigens - chemistry Antigens - immunology Antigens - metabolism ARCHITECTURE BIOLOGY CHIMERAS CRYSTAL STRUCTURE Crystallography, X-Ray DISEASES Epitopes - chemistry Epitopes - immunology Epitopes - metabolism Humans Immunoglobulin Fab Fragments - chemistry Immunoglobulin Fab Fragments - immunology Immunoglobulin Fab Fragments - metabolism Interleukin-18 - chemistry Interleukin-18 - immunology Interleukin-18 - metabolism LYMPHOCYTES LYMPHOKINES MATERIALS SCIENCE Mice PATHOGENESIS PLASTICITY Protein Binding - immunology Protein Structure and Folding Protein Structure, Quaternary Protein Structure, Secondary Protein Structure, Tertiary RESIDUES RESOLUTION WATER Water - chemistry
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