Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” Antagonists

Chemokine receptors constitute an attractive family of drug targets in the frame of inflammatory diseases. However, targeting specific chemokine receptors may be complicated by their ability to form dimers or higher order oligomers. Using a combination of luminescence complementation and bioluminesc...

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Veröffentlicht in:	The Journal of biological chemistry 2009-11, Vol.284 (45), p.31270-31279
Hauptverfasser:	Sohy, Denis, Yano, Hideaki, de Nadai, Patricia, Urizar, Eneko, Guillabert, Aude, Javitch, Jonathan A., Parmentier, Marc, Springael, Jean-Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Animals CCR5 Receptor Antagonists Cell Line Cells, Cultured Heterocyclic Compounds - pharmacology Humans Life Sciences Mechanisms of Signal Transduction Mice Mice, Inbred BALB C Monocytes - chemistry Monocytes - metabolism Protein Multimerization - drug effects Quaternary Ammonium Compounds - pharmacology Receptors, CCR2 - antagonists & inhibitors Receptors, CCR2 - chemistry Receptors, CCR5 - chemistry Receptors, CXCR4 - antagonists & inhibitors Receptors, CXCR4 - chemistry T-Lymphocytes - chemistry T-Lymphocytes - metabolism
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