Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology
Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to...
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| Veröffentlicht in: | Clinical cases in mineral and bone metabolism 2008-05, Vol.5 (2), p.107-109 |
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| creator | Gambaro, Giovanni Fabris, Antonia Abaterusso, Cataldo Cosaro, Alex Ceol, Monica Mezzabotta, Federica Torregrossa, Rossella Tiralongo, Emilia Del Prete, Dorella D'Angelo, Angela Anglani, Franca |
| description | Randall's plaques are very common in idiopathic calcium-oxalate nephrolithiasis. These papillary plaques have an apatite mineral structure. While these calcium deposits are generally assumed to be secondary to a purely physico-chemical phenomenon, we advance the hypothesis that they form due to a truly ectopic biomineralization in the renal tissue, and that Henle's loop epithelial cells, or pericyte-like interstitial cells, or papillary stem cells differentiating along a bone lineage might be involved. |
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| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Mini-Review |
| title | Pathogenesis of nephrolithiasis: recent insight from cell biology and renal pathology |
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