The structural and functional determinants of the Axin and Dishevelled DIX domains

The dishevelled and axin genes encode multi-domain proteins that play key roles in WNT signalling. Dishevelled prevents beta-catenin degradation by interfering with the interaction of beta-catenin with the degradation-mediating Axin-APC-GSK3beta complex. This interference leads to an accumulation of...

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Veröffentlicht in:	BMC structural biology 2009-11, Vol.9 (1), p.70-70
Hauptverfasser:	Ehebauer, Matthias T, Arias, Alfonso Martinez
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Amino Acid Sequence Animals Axin Protein Dimerization Dishevelled Proteins Evolution, Molecular Humans Molecular Sequence Data Mutation Phenotype Phosphoproteins - chemistry Protein Interaction Domains and Motifs Protein Structure, Tertiary Rats Repressor Proteins - chemistry Research article Sequence Alignment
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