Replication profile of PCDH11X and PCDH11Y, a gene pair located in the non-pseudoautosomal homologous region Xq21.3/Yp11.2
In order to investigate the replication timing properties of PCDH11X and PCDH11Y, a pair of protocadherin genes located in the hominid-specific non-pseudoautosomal homologous region Xq21.3/Yp11.2, we conducted a FISH-based comparative study in different human and non-human primate (Gorilla gorilla)...
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| Veröffentlicht in: | Chromosome research 2007-06, Vol.15 (4), p.485-498 |
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| creator | Wilson, N. D Ross, L. J. N Close, J Mott, R Crow, T. J Volpi, E. V |
| description | In order to investigate the replication timing properties of PCDH11X and PCDH11Y, a pair of protocadherin genes located in the hominid-specific non-pseudoautosomal homologous region Xq21.3/Yp11.2, we conducted a FISH-based comparative study in different human and non-human primate (Gorilla gorilla) cell types. The replication profiles of three genes from different regions of chromosome X (ZFX, XIST and ATRX) were used as terms of reference. Particular emphasis was given to the evaluation of allelic replication asynchrony in relation to the inactivation status of each gene. The human cell types analysed include neuronal cells and ICF syndrome cells, considered to be a model system for the study of X inactivation. PCDH11 appeared to be generally characterized by replication asynchrony in both male and female cells, and no significant differences were observed between human and gorilla, in which this gene lacks X-Y homologous status. However, in differentiated human neuroblastoma and cerebral cortical cells PCDH11X replication profile showed a significant shift towards allelic synchrony. Our data are relevant to the complex relationship between X-inactivation, as a chromosome-wide phenomenon, and asynchrony of replication and expression status of single genes on chromosome X. |
| doi_str_mv | 10.1007/s10577-007-1153-y |
| format | Article |
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D ; Ross, L. J. N ; Close, J ; Mott, R ; Crow, T. J ; Volpi, E. V</creator><creatorcontrib>Wilson, N. D ; Ross, L. J. N ; Close, J ; Mott, R ; Crow, T. J ; Volpi, E. V</creatorcontrib><description>In order to investigate the replication timing properties of PCDH11X and PCDH11Y, a pair of protocadherin genes located in the hominid-specific non-pseudoautosomal homologous region Xq21.3/Yp11.2, we conducted a FISH-based comparative study in different human and non-human primate (Gorilla gorilla) cell types. The replication profiles of three genes from different regions of chromosome X (ZFX, XIST and ATRX) were used as terms of reference. Particular emphasis was given to the evaluation of allelic replication asynchrony in relation to the inactivation status of each gene. The human cell types analysed include neuronal cells and ICF syndrome cells, considered to be a model system for the study of X inactivation. PCDH11 appeared to be generally characterized by replication asynchrony in both male and female cells, and no significant differences were observed between human and gorilla, in which this gene lacks X-Y homologous status. However, in differentiated human neuroblastoma and cerebral cortical cells PCDH11X replication profile showed a significant shift towards allelic synchrony. Our data are relevant to the complex relationship between X-inactivation, as a chromosome-wide phenomenon, and asynchrony of replication and expression status of single genes on chromosome X.</description><identifier>ISSN: 0967-3849</identifier><identifier>EISSN: 1573-6849</identifier><identifier>DOI: 10.1007/s10577-007-1153-y</identifier><identifier>PMID: 17671842</identifier><language>eng</language><publisher>Netherlands: Dordrecht : Springer Netherlands</publisher><subject>Animals ; Base Sequence ; Cadherins - genetics ; Cell Line ; Chromosomes ; Chromosomes, Human, X - genetics ; Chromosomes, Human, Y - genetics ; DNA Primers - genetics ; Female ; Genomics ; Gorilla gorilla ; Gorilla gorilla - genetics ; Humans ; In Situ Hybridization, Fluorescence ; Male ; PCDH11X/Y ; Primates ; Protocadherins ; replication asynchrony ; replication timing ; Species Specificity ; X Chromosome - genetics ; X Chromosome Inactivation ; X-inactivation ; Xq21.3/Yp11.2 homology block ; Y Chromosome - genetics</subject><ispartof>Chromosome research, 2007-06, Vol.15 (4), p.485-498</ispartof><rights>Springer 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-8364261ea70dcd9ba2943632b75a9bcc3245cf23644b79196d0b7687a6d1ec3c3</citedby><cites>FETCH-LOGICAL-c576t-8364261ea70dcd9ba2943632b75a9bcc3245cf23644b79196d0b7687a6d1ec3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17671842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilson, N. D</creatorcontrib><creatorcontrib>Ross, L. J. N</creatorcontrib><creatorcontrib>Close, J</creatorcontrib><creatorcontrib>Mott, R</creatorcontrib><creatorcontrib>Crow, T. J</creatorcontrib><creatorcontrib>Volpi, E. V</creatorcontrib><title>Replication profile of PCDH11X and PCDH11Y, a gene pair located in the non-pseudoautosomal homologous region Xq21.3/Yp11.2</title><title>Chromosome research</title><addtitle>Chromosome Res</addtitle><description>In order to investigate the replication timing properties of PCDH11X and PCDH11Y, a pair of protocadherin genes located in the hominid-specific non-pseudoautosomal homologous region Xq21.3/Yp11.2, we conducted a FISH-based comparative study in different human and non-human primate (Gorilla gorilla) cell types. The replication profiles of three genes from different regions of chromosome X (ZFX, XIST and ATRX) were used as terms of reference. Particular emphasis was given to the evaluation of allelic replication asynchrony in relation to the inactivation status of each gene. The human cell types analysed include neuronal cells and ICF syndrome cells, considered to be a model system for the study of X inactivation. PCDH11 appeared to be generally characterized by replication asynchrony in both male and female cells, and no significant differences were observed between human and gorilla, in which this gene lacks X-Y homologous status. However, in differentiated human neuroblastoma and cerebral cortical cells PCDH11X replication profile showed a significant shift towards allelic synchrony. Our data are relevant to the complex relationship between X-inactivation, as a chromosome-wide phenomenon, and asynchrony of replication and expression status of single genes on chromosome X.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Cadherins - genetics</subject><subject>Cell Line</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, X - genetics</subject><subject>Chromosomes, Human, Y - genetics</subject><subject>DNA Primers - genetics</subject><subject>Female</subject><subject>Genomics</subject><subject>Gorilla gorilla</subject><subject>Gorilla gorilla - genetics</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Male</subject><subject>PCDH11X/Y</subject><subject>Primates</subject><subject>Protocadherins</subject><subject>replication asynchrony</subject><subject>replication timing</subject><subject>Species Specificity</subject><subject>X Chromosome - genetics</subject><subject>X Chromosome Inactivation</subject><subject>X-inactivation</subject><subject>Xq21.3/Yp11.2 homology block</subject><subject>Y Chromosome - genetics</subject><issn>0967-3849</issn><issn>1573-6849</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkktv1DAUhSMEokPhB7ABiwUrMvX1M95UQsOjSJVAQKV2ZTmOk0mVsVM7QRp-PY5mxGvTlY_k7x7fe32K4jngNWAszxJgLmWZZQnAabl_UKyAS1qKiqmHxQorIUua9UnxJKVbjHFFGTwuTkAKCRUjq-LnVzcOvTVTHzwaY2j7waHQoi-bdxcA18j45qhv3iCDOucdGk0f0RBykWtQ79G0dcgHX47JzU0w8xRS2JkBbcMuDKELc0LRdcsD13cE1vTsZgRYk6fFo9YMyT07nqfF1Yf33zcX5eXnj582by9Ly6WYyooKRgQ4I3FjG1UbohgVlNSSG1VbSwnjtiWZYrVUoESDaykqaUQDzlJLT4vzg-841zvXWOenaAY9xn5n4l4H0-t_b3y_1V34oYmUilY8G7w-GsRwN7s06V2frBsG410eTosKgGTuXpAAwUJhuB_EIv8jrzL46j_wNszR53Xl7hgwztnyLBwgG0NK0bW_ZwOsl6DoQ1D0Ipeg6H2uefH3Uv5UHJORgZcHoDVBmy72SV99I7n3bFJJzBT9BUA7wH4</recordid><startdate>200706</startdate><enddate>200706</enddate><creator>Wilson, N. 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D</au><au>Ross, L. J. N</au><au>Close, J</au><au>Mott, R</au><au>Crow, T. J</au><au>Volpi, E. V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Replication profile of PCDH11X and PCDH11Y, a gene pair located in the non-pseudoautosomal homologous region Xq21.3/Yp11.2</atitle><jtitle>Chromosome research</jtitle><addtitle>Chromosome Res</addtitle><date>2007-06</date><risdate>2007</risdate><volume>15</volume><issue>4</issue><spage>485</spage><epage>498</epage><pages>485-498</pages><issn>0967-3849</issn><eissn>1573-6849</eissn><abstract>In order to investigate the replication timing properties of PCDH11X and PCDH11Y, a pair of protocadherin genes located in the hominid-specific non-pseudoautosomal homologous region Xq21.3/Yp11.2, we conducted a FISH-based comparative study in different human and non-human primate (Gorilla gorilla) cell types. The replication profiles of three genes from different regions of chromosome X (ZFX, XIST and ATRX) were used as terms of reference. Particular emphasis was given to the evaluation of allelic replication asynchrony in relation to the inactivation status of each gene. The human cell types analysed include neuronal cells and ICF syndrome cells, considered to be a model system for the study of X inactivation. PCDH11 appeared to be generally characterized by replication asynchrony in both male and female cells, and no significant differences were observed between human and gorilla, in which this gene lacks X-Y homologous status. However, in differentiated human neuroblastoma and cerebral cortical cells PCDH11X replication profile showed a significant shift towards allelic synchrony. Our data are relevant to the complex relationship between X-inactivation, as a chromosome-wide phenomenon, and asynchrony of replication and expression status of single genes on chromosome X.</abstract><cop>Netherlands</cop><pub>Dordrecht : Springer Netherlands</pub><pmid>17671842</pmid><doi>10.1007/s10577-007-1153-y</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chromosome research, 2007-06, Vol.15 (4), p.485-498 |
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| subjects | Animals Base Sequence Cadherins - genetics Cell Line Chromosomes Chromosomes, Human, X - genetics Chromosomes, Human, Y - genetics DNA Primers - genetics Female Genomics Gorilla gorilla Gorilla gorilla - genetics Humans In Situ Hybridization, Fluorescence Male PCDH11X/Y Primates Protocadherins replication asynchrony replication timing Species Specificity X Chromosome - genetics X Chromosome Inactivation X-inactivation Xq21.3/Yp11.2 homology block Y Chromosome - genetics |
| title | Replication profile of PCDH11X and PCDH11Y, a gene pair located in the non-pseudoautosomal homologous region Xq21.3/Yp11.2 |
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