Programmed Death-1 (PD-1):PD-Ligand 1 Interactions Inhibit TCR-Mediated Positive Selection of Thymocytes

Positive selection during thymocyte development is driven by the affinity and avidity of the TCR for MHC-peptide complexes expressed in the thymus. In this study, we show that programmed death-1 (PD-1), a member of the B7/CD28 family of costimulatory receptors, inhibits TCR-mediated positive selecti...

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Veröffentlicht in:	Journal of Immunology 2005-12, Vol.175 (11), p.7372-7379
Hauptverfasser:	Keir, Mary E, Latchman, Yvette E, Freeman, Gordon J, Sharpe, Arlene H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - immunology Antigens, Differentiation - metabolism B7-1 Antigen - immunology B7-1 Antigen - metabolism B7-H1 Antigen CD2 Antigens - immunology CD2 Antigens - metabolism CD28 Antigens - immunology CD28 Antigens - metabolism CD4 Antigens - immunology CD4 Antigens - metabolism CD8 Antigens - immunology CD8 Antigens - metabolism Cell Differentiation - immunology Clonal Deletion - immunology Extracellular Signal-Regulated MAP Kinases - metabolism Flow Cytometry Immune Tolerance - immunology Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Peptides - immunology Peptides - metabolism Programmed Cell Death 1 Ligand 2 Protein Programmed Cell Death 1 Receptor Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Thymus Gland - cytology Thymus Gland - growth & development Thymus Gland - immunology
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