Accelerating regional atrophy rates in the progression from normal aging to Alzheimer’s disease
We investigated progression of atrophy in vivo, in Alzheimer’s disease (AD), and mild cognitive impairment (MCI). We included 64 patients with AD, 44 with MCI and 34 controls with serial MRI examinations (interval 1.8 ± 0.7 years). A nonlinear registration algorithm (fluid) was used to calculate atr...
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| Veröffentlicht in: | European radiology 2009-12, Vol.19 (12), p.2826-2833 |
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| creator | Sluimer, Jasper D. van der Flier, Wiesje M. Karas, Giorgos B. van Schijndel, Ronald Barnes, Josephine Boyes, Richard G. Cover, Keith S. Olabarriaga, Sílvia D. Fox, Nick C. Scheltens, Philip Vrenken, Hugo Barkhof, Frederik |
| description | We investigated progression of atrophy in vivo, in Alzheimer’s disease (AD), and mild cognitive impairment (MCI). We included 64 patients with AD, 44 with MCI and 34 controls with serial MRI examinations (interval 1.8 ± 0.7 years). A nonlinear registration algorithm (fluid) was used to calculate atrophy rates in six regions: frontal, medial temporal, temporal (extramedial), parietal, occipital lobes and insular cortex. In MCI, the highest atrophy rate was observed in the medial temporal lobe, comparable with AD. AD patients showed even higher atrophy rates in the extramedial temporal lobe. Additionally, atrophy rates in frontal, parietal and occipital lobes were increased. Cox proportional hazard models showed that all regional atrophy rates predicted conversion to AD. Hazard ratios varied between 2.6 (95% confidence interval (CI) = 1.1–6.2) for occipital atrophy and 15.8 (95% CI = 3.5–71.8) for medial temporal lobe atrophy. In conclusion, atrophy spreads through the brain with development of AD. MCI is marked by temporal lobe atrophy. In AD, atrophy rate in the extramedial temporal lobe was even higher. Moreover, atrophy rates also accelerated in parietal, frontal, insular and occipital lobes. Finally, in nondemented elderly, medial temporal lobe atrophy was most predictive of progression to AD, demonstrating the involvement of this region in the development of AD. |
| doi_str_mv | 10.1007/s00330-009-1512-5 |
| format | Article |
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We included 64 patients with AD, 44 with MCI and 34 controls with serial MRI examinations (interval 1.8 ± 0.7 years). A nonlinear registration algorithm (fluid) was used to calculate atrophy rates in six regions: frontal, medial temporal, temporal (extramedial), parietal, occipital lobes and insular cortex. In MCI, the highest atrophy rate was observed in the medial temporal lobe, comparable with AD. AD patients showed even higher atrophy rates in the extramedial temporal lobe. Additionally, atrophy rates in frontal, parietal and occipital lobes were increased. Cox proportional hazard models showed that all regional atrophy rates predicted conversion to AD. Hazard ratios varied between 2.6 (95% confidence interval (CI) = 1.1–6.2) for occipital atrophy and 15.8 (95% CI = 3.5–71.8) for medial temporal lobe atrophy. In conclusion, atrophy spreads through the brain with development of AD. MCI is marked by temporal lobe atrophy. In AD, atrophy rate in the extramedial temporal lobe was even higher. Moreover, atrophy rates also accelerated in parietal, frontal, insular and occipital lobes. Finally, in nondemented elderly, medial temporal lobe atrophy was most predictive of progression to AD, demonstrating the involvement of this region in the development of AD.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-009-1512-5</identifier><identifier>PMID: 19618189</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Aged ; Aging - pathology ; Alzheimer Disease - complications ; Alzheimer Disease - pathology ; Alzheimer's disease ; Atrophy ; Atrophy - pathology ; Brain ; Brain - pathology ; Cognition Disorders - etiology ; Cognition Disorders - pathology ; Cognitive ability ; Dementia ; Diagnostic Radiology ; Disease ; Female ; Humans ; Imaging ; Internal Medicine ; Interventional Radiology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine & Public Health ; Memory ; Neuro ; Neuropathology ; Neuroradiology ; Pathology ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; Ultrasound</subject><ispartof>European radiology, 2009-12, Vol.19 (12), p.2826-2833</ispartof><rights>The Author(s) 2009</rights><rights>European Society of Radiology 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-ba7c163c2cb4e5b4928e01dac006084afcb6b192dfd96291a1cba17a09b100cc3</citedby><cites>FETCH-LOGICAL-c499t-ba7c163c2cb4e5b4928e01dac006084afcb6b192dfd96291a1cba17a09b100cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-009-1512-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-009-1512-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19618189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sluimer, Jasper D.</creatorcontrib><creatorcontrib>van der Flier, Wiesje M.</creatorcontrib><creatorcontrib>Karas, Giorgos B.</creatorcontrib><creatorcontrib>van Schijndel, Ronald</creatorcontrib><creatorcontrib>Barnes, Josephine</creatorcontrib><creatorcontrib>Boyes, Richard G.</creatorcontrib><creatorcontrib>Cover, Keith S.</creatorcontrib><creatorcontrib>Olabarriaga, Sílvia D.</creatorcontrib><creatorcontrib>Fox, Nick C.</creatorcontrib><creatorcontrib>Scheltens, Philip</creatorcontrib><creatorcontrib>Vrenken, Hugo</creatorcontrib><creatorcontrib>Barkhof, Frederik</creatorcontrib><title>Accelerating regional atrophy rates in the progression from normal aging to Alzheimer’s disease</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>We investigated progression of atrophy in vivo, in Alzheimer’s disease (AD), and mild cognitive impairment (MCI). We included 64 patients with AD, 44 with MCI and 34 controls with serial MRI examinations (interval 1.8 ± 0.7 years). A nonlinear registration algorithm (fluid) was used to calculate atrophy rates in six regions: frontal, medial temporal, temporal (extramedial), parietal, occipital lobes and insular cortex. In MCI, the highest atrophy rate was observed in the medial temporal lobe, comparable with AD. AD patients showed even higher atrophy rates in the extramedial temporal lobe. Additionally, atrophy rates in frontal, parietal and occipital lobes were increased. Cox proportional hazard models showed that all regional atrophy rates predicted conversion to AD. Hazard ratios varied between 2.6 (95% confidence interval (CI) = 1.1–6.2) for occipital atrophy and 15.8 (95% CI = 3.5–71.8) for medial temporal lobe atrophy. In conclusion, atrophy spreads through the brain with development of AD. MCI is marked by temporal lobe atrophy. In AD, atrophy rate in the extramedial temporal lobe was even higher. Moreover, atrophy rates also accelerated in parietal, frontal, insular and occipital lobes. Finally, in nondemented elderly, medial temporal lobe atrophy was most predictive of progression to AD, demonstrating the involvement of this region in the development of AD.</description><subject>Aged</subject><subject>Aging - pathology</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer's disease</subject><subject>Atrophy</subject><subject>Atrophy - pathology</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - pathology</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Diagnostic Radiology</subject><subject>Disease</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Memory</subject><subject>Neuro</subject><subject>Neuropathology</subject><subject>Neuroradiology</subject><subject>Pathology</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kcGK1TAUhoMoznX0AdxIcOGsquekadNshMvgqDDgRtchTU97M7TNNekVxpWv4ev5JKbci6OCrgI53_8n5_8Ze4rwEgHUqwRQllAA6AIrFEV1j21QlqJAaOR9tgFdNoXSWp6xRyndQAZRqofsDHWNDTZ6w-zWORop2sXPA480-DDbkdslhv3ulud7StzPfNkR38cwREopI7yPYeJziNMKD6t2CXw7ft2Rnyj--PY98c4nsokeswe9HRM9OZ3n7NPVm4-X74rrD2_fX26vCye1XorWKod16YRrJVWt1KIhwM46gDpvY3vX1i1q0fWdroVGi661qCzoNmfhXHnOXh9994d2os7RvEQ7mn30k423Jlhv_pzMfmeG8MUIpRqlymxwcTKI4fOB0mImn3I4o50pHJJRpRSVkFWTyRf_JQWKWlX1Cj7_C7wJh5gDXplGQy6rzhAeIRdDSpH6X39GMGvP5tizyfWZtWdTZc2z35e9U5yKzYA4AimP5oHi3cv_dv0JGTW2FQ</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Sluimer, Jasper D.</creator><creator>van der Flier, Wiesje M.</creator><creator>Karas, Giorgos B.</creator><creator>van Schijndel, Ronald</creator><creator>Barnes, Josephine</creator><creator>Boyes, Richard G.</creator><creator>Cover, Keith S.</creator><creator>Olabarriaga, Sílvia D.</creator><creator>Fox, Nick C.</creator><creator>Scheltens, Philip</creator><creator>Vrenken, Hugo</creator><creator>Barkhof, Frederik</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091201</creationdate><title>Accelerating regional atrophy rates in the progression from normal aging to Alzheimer’s disease</title><author>Sluimer, Jasper D. ; van der Flier, Wiesje M. ; Karas, Giorgos B. ; van Schijndel, Ronald ; Barnes, Josephine ; Boyes, Richard G. ; Cover, Keith S. ; Olabarriaga, Sílvia D. ; Fox, Nick C. ; Scheltens, Philip ; Vrenken, Hugo ; Barkhof, Frederik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-ba7c163c2cb4e5b4928e01dac006084afcb6b192dfd96291a1cba17a09b100cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aging - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sluimer, Jasper D.</au><au>van der Flier, Wiesje M.</au><au>Karas, Giorgos B.</au><au>van Schijndel, Ronald</au><au>Barnes, Josephine</au><au>Boyes, Richard G.</au><au>Cover, Keith S.</au><au>Olabarriaga, Sílvia D.</au><au>Fox, Nick C.</au><au>Scheltens, Philip</au><au>Vrenken, Hugo</au><au>Barkhof, Frederik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accelerating regional atrophy rates in the progression from normal aging to Alzheimer’s disease</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>19</volume><issue>12</issue><spage>2826</spage><epage>2833</epage><pages>2826-2833</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>We investigated progression of atrophy in vivo, in Alzheimer’s disease (AD), and mild cognitive impairment (MCI). We included 64 patients with AD, 44 with MCI and 34 controls with serial MRI examinations (interval 1.8 ± 0.7 years). A nonlinear registration algorithm (fluid) was used to calculate atrophy rates in six regions: frontal, medial temporal, temporal (extramedial), parietal, occipital lobes and insular cortex. In MCI, the highest atrophy rate was observed in the medial temporal lobe, comparable with AD. AD patients showed even higher atrophy rates in the extramedial temporal lobe. Additionally, atrophy rates in frontal, parietal and occipital lobes were increased. Cox proportional hazard models showed that all regional atrophy rates predicted conversion to AD. Hazard ratios varied between 2.6 (95% confidence interval (CI) = 1.1–6.2) for occipital atrophy and 15.8 (95% CI = 3.5–71.8) for medial temporal lobe atrophy. In conclusion, atrophy spreads through the brain with development of AD. MCI is marked by temporal lobe atrophy. In AD, atrophy rate in the extramedial temporal lobe was even higher. Moreover, atrophy rates also accelerated in parietal, frontal, insular and occipital lobes. Finally, in nondemented elderly, medial temporal lobe atrophy was most predictive of progression to AD, demonstrating the involvement of this region in the development of AD.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19618189</pmid><doi>10.1007/s00330-009-1512-5</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aging - pathology Alzheimer Disease - complications Alzheimer Disease - pathology Alzheimer's disease Atrophy Atrophy - pathology Brain Brain - pathology Cognition Disorders - etiology Cognition Disorders - pathology Cognitive ability Dementia Diagnostic Radiology Disease Female Humans Imaging Internal Medicine Interventional Radiology Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Memory Neuro Neuropathology Neuroradiology Pathology Radiology Reproducibility of Results Sensitivity and Specificity Ultrasound |
| title | Accelerating regional atrophy rates in the progression from normal aging to Alzheimer’s disease |
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