Semaphorin3a regulates endothelial cell number and podocyte differentiation during glomerular development

Semaphorin3a ( Sema3a ), a chemorepellant guidance protein, plays crucial roles in neural, cardiac and peripheral vascular patterning. Sema3a is expressed in the developing nephron, mature podocytes and collecting tubules. Sema3a acts as a negative regulator of ureteric bud branching, but its functi...

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Veröffentlicht in:	Development (Cambridge) 2009-12, Vol.136 (23), p.3979-3989
Hauptverfasser:	Reidy, Kimberly J, Villegas, Guillermo, Teichman, Jason, Veron, Delma, Shen, Wa, Jimenez, Juan, Thomas, David, Tufro, Alda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Cell Count Cell Differentiation - genetics Cell Nucleus - metabolism Coculture Techniques Endothelial Cells - metabolism Endothelial Cells - physiology Endothelial Cells - ultrastructure Fluorescent Antibody Technique, Direct Fluorescent Dyes - metabolism Gene Deletion Gene Expression Regulation, Developmental Griffonia - chemistry Immunohistochemistry In Situ Nick-End Labeling Indoles - metabolism Kidney Glomerulus - growth & development Kidney Glomerulus - ultrastructure Mice Mice, Knockout Mice, Mutant Strains Mice, Transgenic Plant Lectins - metabolism Podocytes - cytology Podocytes - metabolism Podocytes - physiology Podocytes - ultrastructure Rats Recombinant Proteins - metabolism Semaphorin-3A - genetics Semaphorin-3A - metabolism Semaphorin-3A - physiology
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