Regulation of the Protein-Conducting Channel by a Bound Ribosome

During protein synthesis, it is often necessary for the ribosome to form a complex with a membrane-bound channel, the SecY/Sec61 complex, in order to translocate nascent proteins across a cellular membrane. Structural data on the ribosome-channel complex are currently limited to low-resolution cryo-...

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Veröffentlicht in:	Structure (London) 2009-11, Vol.17 (11), p.1453-1464
Hauptverfasser:	Gumbart, James, Trabuco, Leonardo G., Schreiner, Eduard, Villa, Elizabeth, Schulten, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer Simulation Cryoelectron Microscopy DNA Escherichia coli Proteins - chemistry Membrane Proteins - chemistry Membrane Proteins - metabolism Membrane Proteins - ultrastructure Methanococcus - chemistry Models, Molecular PROTEINS Ribosomes - chemistry Ribosomes - metabolism Ribosomes - ultrastructure RNA SEC Translocation Channels
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