Humanised IgG1 antibody variants targeting membrane-bound carcinoembryonic antigen by antibody-dependent cellular cytotoxicity and phagocytosis

Background: The effect of glycoengineering a membrane specific anti-carcinoembryonic antigen (CEA) (this paper uses the original term CEA for the formally designated CEACAM5) antibody (PR1A3) on its ability to enhance killing of colorectal cancer (CRC) cell lines by human immune effector cells was a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 2009-11, Vol.101 (10), p.1758-1768
Hauptverfasser:	Ashraf, S Q, Umana, P, Mössner, E, Ntouroupi, T, Brünker, P, Schmidt, C, Wilding, J L, Mortensen, N J, Bodmer, W F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - genetics Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antibody-Dependent Cell Cytotoxicity - drug effects Antibody-Dependent Cell Cytotoxicity - immunology Antigens Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Carcinoembryonic Antigen - immunology Cell Line, Tumor Clinical trials Colorectal cancer Colorectal Neoplasms - immunology Colorectal Neoplasms - therapy Cytotoxicity Drug Resistance Epidemiology Flow Cytometry Granulocytes Hematology Humans Immune system Immunoglobulin G - genetics Immunoglobulin G - immunology Immunoglobulin G - pharmacology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Medical research Mice Mice, SCID Molecular Diagnostics Molecular Medicine Oncology Phagocytosis - drug effects Phagocytosis - immunology Protein Engineering - methods Receptors, IgG - antagonists & inhibitors Receptors, IgG - immunology Transfection Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!