Deoxyribonuclease IV: A New Exonuclease from Mammalian Tissues

An exonuclease which specifically degrades double-stranded DNA has been isolated from rabbit tissues. The enzyme has an approximate molecular weight of 42,000, requires a divalent metal ion as cofactor, and attacks DNA at the 5′-terminal ends, thereby liberating 5′-mononucleotides. It degrades sever...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1969-02, Vol.62 (2), p.597-603
Hauptverfasser:	Lindahl, Tomas, Gally, Joseph A., Edelman, Gerald M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological Sciences: Biochemistry Bone marrow Bone Marrow - enzymology Cellulose Centrifugation Centrifugation, Zonal Chemical Phenomena Chemistry Chromatography Deoxyribonucleases - analysis DNA Enzymes Hydrolysis Hydroxyapatites Kinetics Molecular Weight Nucleotides Phosphorus Isotopes Polymers Polynucleotides Rabbits Sodium Tritium
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