Nuclear apoptosis contributes to sarcopenia
Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss o...
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| Veröffentlicht in: | Exercise and sport sciences reviews 2008-04, Vol.36 (2), p.51-57 |
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| container_title | Exercise and sport sciences reviews |
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| creator | Alway, Stephen E Siu, Parco M |
| description | Apoptosis results in DNA fragmentation and, subsequently, destruction of cells containing a single nucleus. Our hypothesis is that multinucleated cells such as muscle fibers can experience apoptotic-induced loss of single nuclei (nuclear apoptosis) without destruction of the entire fiber. The loss of nuclei likely contributes to atrophy and sarcopenia. Furthermore, increased chronic activity attenuates apoptotic signaling, which may reduce sarcopenia. |
| doi_str_mv | 10.1097/JES.0b013e318168e9dc |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0091-6331 |
| ispartof | Exercise and sport sciences reviews, 2008-04, Vol.36 (2), p.51-57 |
| issn | 0091-6331 1538-3008 |
| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aging - physiology Animals Apoptosis - physiology Cell Nucleus - physiology Cytochromes c - analysis Exercise - physiology Humans Muscle Contraction - physiology Muscle, Skeletal - chemistry Muscular Atrophy - physiopathology Satellite Cells, Skeletal Muscle - physiology |
| title | Nuclear apoptosis contributes to sarcopenia |
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