Pannexin 1 Contributes to ATP Release in Airway Epithelia

ATP is a paracrine regulator of critical airway epithelial cell functions, but the mechanism of its release is poorly understood. Pannexin (Panx) proteins, related to invertebrate innexins, form channels (called pannexons) that are able to release ATP from several cell types. Thus, ATP release via p...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2009-11, Vol.41 (5), p.525-534
Hauptverfasser:	Ransford, George A, Fregien, Nevis, Qiu, Feng, Dahl, Gerhard, Conner, Gregory E, Salathe, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - secretion Animals Carbenoxolone - pharmacology Cell Dedifferentiation Cells, Cultured Connexins - antagonists & inhibitors Connexins - genetics Connexins - metabolism Epithelial Cells - drug effects Epithelial Cells - metabolism Flufenamic Acid - pharmacology Gene Expression Regulation Humans Hypotonic Solutions Macrophages, Alveolar - metabolism Mice Mucociliary Clearance Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Osmotic Pressure Paracrine Communication Probenecid - pharmacology Respiratory Mucosa - drug effects Respiratory Mucosa - metabolism Respiratory Mucosa - secretion RNA Interference RNA, Messenger - metabolism Stress, Physiological Time Factors Transfection Xenopus
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