Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1

It is known that siRNAs are capable of reducing expression of non-target genes due to the interaction of the siRNA guide strand with a partially complementary site on the 'off-target' mRNA. In the current study, we show that reduction of cellular Ago2 levels has no effect on off-target red...

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Veröffentlicht in:	Nucleic acids research 2009-11, Vol.37 (20), p.6927-6941
Hauptverfasser:	Vickers, Timothy A, Lima, Walt F, Wu, Hongjiang, Nichols, Josh G, Linsley, Peter S, Crooke, Stanley T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Argonaute Proteins Cells, Cultured Class I Phosphatidylinositol 3-Kinases Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factors - metabolism Gene Expression Profiling Humans Mice Mice, Knockout Phosphatidylinositol 3-Kinases - metabolism Ribonuclease III - metabolism RNA RNA Interference RNA Stability RNA, Messenger - metabolism RNA, Small Interfering - metabolism
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