$Acute and persisting Th2-like immune response after fractionated colorectal gamma-irradiation$

Acute and persisting Th2-like immune response after fractionated colorectal gamma-irradiation

To investigate if an immune imbalance may account for the development and progression of chronic radiation enteritis. We analyzed the Th1/Th2 immune response profile early and 6 mo after fractionated colorectal irradiation. A rat model of fractionated colorectal gamma-irradiation (4-Gy fractions, 3...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2008-12, Vol.14 (46), p.7075-7085
Hauptverfasser:	Gremy, Olivier, Benderitter, Marc, Linard, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colon - metabolism Colon - pathology Colon - radiation effects Colorectal Cancer Dose-Response Relationship, Radiation Gamma Rays Immunity, Mucosal - radiation effects Interleukin-10 - metabolism Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestinal Mucosa - radiation effects Life Sciences Male Models, Animal Rats Rats, Wistar Rectum - metabolism Rectum - pathology Rectum - radiation effects Signal Transduction - radiation effects STAT3 Transcription Factor - metabolism Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins - metabolism Th1 Cells - metabolism Th1 Cells - pathology Th1 Cells - radiation effects Th2 Cells - metabolism Th2 Cells - pathology Th2 Cells - radiation effects
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