A Model of Na+/H+ Exchanger and Its Central Role in Regulation of pH and Na+ in Cardiac Myocytes

A new kinetic model of the Na+/H+ exchanger (NHE) was developed by fitting a variety of major experimental findings, such as ion-dependencies, forward/reverse mode, and the turnover rate. The role of NHE in ion homeostasis was examined by implementing the NHE model in a minimum cell model including...

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Veröffentlicht in:	Biophysical journal 2009-11, Vol.97 (10), p.2674-2683
Hauptverfasser:	Cha, Chae Young, Oka, Chiaki, Earm, Yung E., Wakabayashi, Shigeo, Noma, Akinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidity Acidosis - metabolism Algorithms Animals Cell Membrane - metabolism Cell Survival - physiology Cells Cellular Biophysics and Electrophysiology Computer Simulation Homeostasis - physiology Hydrogen - metabolism Hydrogen-Ion Concentration Intracellular Space - metabolism Ions Ions - metabolism Kinetics Membranes Models, Cardiovascular Myocytes, Cardiac - physiology Potassium Purkinje Fibers - physiology Sodium Sodium - metabolism Sodium-Hydrogen Exchangers - metabolism
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