Amphipathic motifs in BAR domains are essential for membrane curvature sensing

BAR (Bin/Amphiphysin/Rvs) domains and amphipathic α‐helices (AHs) are believed to be sensors of membrane curvature thus facilitating the assembly of protein complexes on curved membranes. Here, we used quantitative fluorescence microscopy to compare the binding of both motifs on single nanosized lip...

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Veröffentlicht in:	The EMBO journal 2009-11, Vol.28 (21), p.3303-3314
Hauptverfasser:	Bhatia, Vikram K, Madsen, Kenneth L, Bolinger, Pierre-Yves, Kunding, Andreas, Hedegård, Per, Gether, Ulrik, Stamou, Dimitrios
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - genetics Acyltransferases - metabolism amphipathic α-helix Animals BAR domain Binding sites Brain Chemistry Cattle EMBO20 EMBO40 Fluorescence Fluorescence microscopy Gene Expression Lipid Bilayers - chemistry Lipid Bilayers - metabolism Lipids Liposomes - chemistry Liposomes - metabolism membrane curvature sensing membrane insertion Membrane Proteins - genetics Membrane Proteins - metabolism Membranes Microscopy Microscopy, Fluorescence Models, Biological Molecular biology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Protein Binding Protein Structure, Secondary Protein Structure, Tertiary Rats Sensors single liposomes
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