Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole
We demonstrate that incorporation of MnSalen into a protein scaffold enhances the chemoselectivity in sulfoxidation of thioanisole and find that both the polarity and hydrogen bonding of the protein scaffold play an important role in tuning the chemoselectivity.
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2008-04 (14), p.1665-1667 |
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| container_end_page | 1667 |
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| container_issue | 14 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Zhang, Jun-Long Garner, Dewain K Liang, Lei Chen, Qian Lu, Yi |
| description | We demonstrate that incorporation of MnSalen into a protein scaffold enhances the chemoselectivity in sulfoxidation of thioanisole and find that both the polarity and hydrogen bonding of the protein scaffold play an important role in tuning the chemoselectivity. |
| doi_str_mv | 10.1039/b718915j |
| format | Article |
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| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2008-04 (14), p.1665-1667 |
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| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Chelating Agents - chemistry chemical compounds chemical reactions chemoselectivity Coenzymes - chemistry Computer Simulation Ethylenediamines - chemistry Hydrogen Bonding Manganese - chemistry Metalloproteases - chemistry Models, Molecular Molecular Structure Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Protein Engineering scaffolding proteins Substrate Specificity Sulfides - chemistry Sulfoxides - chemistry |
| title | Protein scaffold of a designed metalloenzyme enhances the chemoselectivity in sulfoxidation of thioanisole |
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