“Danger” Conditions Increase Sulfamethoxazole-Protein Adduct Formation in Human Antigen-Presenting Cells

Antigen-presenting cells (APC) are thought to play an important role in the pathogenesis of drug-induced immune reactions. Various pathological factors can activate APC and therefore influence the immune equilibrium. It is interesting that several diseases have been associated with an increased rate...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2009-11, Vol.331 (2), p.372-381
Hauptverfasser:	Lavergne, S.N., Wang, H., Callan, H.E., Park, B.K., Naisbitt, D.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - immunology Anti-Infective Agents - metabolism Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism B-Lymphocytes - metabolism Cell Line Cyclohexanones Cytokines - pharmacology Dendritic Cells - metabolism Drug Hypersensitivity - immunology Endotoxins - pharmacology Enzyme Inhibitors - pharmacology Enzyme-Linked Immunosorbent Assay Fever - metabolism Herpesvirus 4, Human - immunology Humans Immunity - drug effects Inflammation Mediators - pharmacology Microscopy, Confocal Monocytes - metabolism Orthomyxoviridae - chemistry Oxidants - pharmacology Sulfamethoxazole - immunology Sulfamethoxazole - metabolism Toxicology Viral Proteins - pharmacology
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