Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein

Using mass spectrometry, we identified ADAM10 (a membrane-associated metalloproteinase) as a partner for TSPAN12, a tetraspanin protein. TSPAN12-ADAM10 interaction was confirmed by reciprocal coimmunoprecipitation in multiple tumor cell lines. TSPAN12, to a greater extent than other tetraspanins (CD...

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Veröffentlicht in:	The FASEB journal 2009-11, Vol.23 (11), p.3674-3681
Hauptverfasser:	Xu, Daosong, Sharma, Chandan, Hemler, Martin E
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - physiology ADAM10 Protein Alzheimer's disease Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases - physiology Cell Line, Tumor Gene Knockdown Techniques Humans Membrane Proteins - genetics Membrane Proteins - physiology Mutation pericellular proteolysis Research Communications Tetraspanins α-secretase
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