Nano-Scaled Particles of Titanium Dioxide Convert Benign Mouse Fibrosarcoma Cells into Aggressive Tumor Cells

Nanoparticles are prevalent in both commercial and medicinal products; however, the contribution of nanomaterials to carcinogenesis remains unclear. We therefore examined the effects of nano-sized titanium dioxide (TiO2 ) on poorly tumorigenic and nonmetastatic QR-32 fibrosarcoma cells. We found tha...

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Veröffentlicht in:	The American journal of pathology 2009-11, Vol.175 (5), p.2171-2183
Hauptverfasser:	Onuma, Kunishige, Sato, Yu, Ogawara, Satomi, Shirasawa, Nobuyuki, Kobayashi, Masanobu, Yoshitake, Jun, Yoshimura, Tetsuhiko, Iigo, Masaaki, Fujii, Junichi, Okada, Futoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line, Tumor Cell Transformation, Neoplastic - drug effects Cytokines - genetics Cytokines - metabolism Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Dinoprostone - metabolism Female Fibrosarcoma - metabolism Fibrosarcoma - pathology Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Investigative techniques, diagnostic techniques (general aspects) Medical sciences Mice Mice, Inbred C57BL Nanoparticles - chemistry Neoplasm Invasiveness - pathology Particle Size Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Reactive Oxygen Species - metabolism Regular Thymosin - genetics Thymosin - metabolism Titanium - chemistry Titanium - pharmacology Vascular Endothelial Growth Factor A - metabolism
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