Karyotype-specific microRNA signature in chronic lymphocytic leukemia

Chromosomal abnormalities, immunoglobulin heavy chain variable–region (IGHV) gene mutation status, and ζ-associated protein 70 (ZAP-70) expression levels have independent prognostic relevance in chronic lymphocytic leukemia (CLL); however, their concordance is variable. Because deregulation of micro...

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Veröffentlicht in:	Blood 2009-10, Vol.114 (18), p.3872-3879
Hauptverfasser:	Visone, Rosa, Rassenti, Laura Z., Veronese, Angelo, Taccioli, Cristian, Costinean, Stefan, Aguda, Baltazar D., Volinia, Stefano, Ferracin, Manuela, Palatini, Jeff, Balatti, Veronica, Alder, Hansjuerg, Negrini, Massimo, Kipps, Thomas J., Croce, Carlo M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Chromosome Deletion Chromosomes, Human Female Gene Expression Regulation, Leukemic Hematologic and hematopoietic diseases Humans Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoid Neoplasia Male Medical sciences MicroRNAs - biosynthesis MicroRNAs - genetics RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics Trisomy ZAP-70 Protein-Tyrosine Kinase - genetics ZAP-70 Protein-Tyrosine Kinase - metabolism
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