Knockdown of CELL DIVISION CYCLE16 Reveals an Inverse Relationship between Lateral Root and Nodule Numbers and a Link to Auxin in Medicago truncatula
The postembryonic development of lateral roots and nodules is a highly regulated process. Recent studies suggest the existence of cross talk and interdependency in the growth of these two organs. Although plant hormones, including auxin and cytokinin, appear to be key players in coordinating this cr...
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| Veröffentlicht in: | Plant physiology (Bethesda) 2009-11, Vol.151 (3), p.1155-1166 |
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| creator | Kuppusamy, Kavitha T Ivashuta, Sergey Bucciarelli, Bruna Vance, Carroll P Gantt, J. Stephen VandenBosch, Kathryn A |
| description | The postembryonic development of lateral roots and nodules is a highly regulated process. Recent studies suggest the existence of cross talk and interdependency in the growth of these two organs. Although plant hormones, including auxin and cytokinin, appear to be key players in coordinating this cross talk, very few genes that cross-regulate root and nodule development have been uncovered so far. This study reports that a homolog of CELL DIVISION CYCLE16 (CDC16), a core component of the Anaphase Promoting Complex, is one of the key mediators in controlling the overall number of lateral roots and nodules. A partial suppression of this gene in Medicago truncatula leads to a decrease in number of lateral roots and a 4-fold increase in number of nodules. The roots showing lowered expression of MtCDC16 also show reduced sensitivity to phytohormone auxin, thus providing a potential function of CDC16 in auxin signaling. |
| doi_str_mv | 10.1104/pp.109.143024 |
| format | Article |
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Stephen ; VandenBosch, Kathryn A</creator><creatorcontrib>Kuppusamy, Kavitha T ; Ivashuta, Sergey ; Bucciarelli, Bruna ; Vance, Carroll P ; Gantt, J. Stephen ; VandenBosch, Kathryn A</creatorcontrib><description>The postembryonic development of lateral roots and nodules is a highly regulated process. Recent studies suggest the existence of cross talk and interdependency in the growth of these two organs. Although plant hormones, including auxin and cytokinin, appear to be key players in coordinating this cross talk, very few genes that cross-regulate root and nodule development have been uncovered so far. This study reports that a homolog of CELL DIVISION CYCLE16 (CDC16), a core component of the Anaphase Promoting Complex, is one of the key mediators in controlling the overall number of lateral roots and nodules. A partial suppression of this gene in Medicago truncatula leads to a decrease in number of lateral roots and a 4-fold increase in number of nodules. The roots showing lowered expression of MtCDC16 also show reduced sensitivity to phytohormone auxin, thus providing a potential function of CDC16 in auxin signaling.</description><identifier>ISSN: 0032-0889</identifier><identifier>ISSN: 1532-2548</identifier><identifier>EISSN: 1532-2548</identifier><identifier>DOI: 10.1104/pp.109.143024</identifier><identifier>PMID: 19789288</identifier><language>eng</language><publisher>United States: American Society of Plant Biologists</publisher><subject>Amino Acid Sequence ; Auxins ; biochemical pathways ; Cell Cycle Proteins ; Cell Cycle Proteins - genetics ; Cell Cycle Proteins - metabolism ; cell morphology ; cytology ; Developmental biology ; DNA, Plant ; DNA, Plant - genetics ; Focus Issue on Legume Biology ; Gene expression regulation ; Gene Expression Regulation, Plant ; Gene Knockdown Techniques ; gene silencing ; gene targeting ; genes ; genetics ; growth & development ; growth and development ; hypernodulation ; Indoleacetic Acids ; Indoleacetic Acids - metabolism ; length ; Medicago truncatula ; Medicago truncatula - cytology ; Medicago truncatula - genetics ; Medicago truncatula - growth & development ; metabolism ; Molecular Sequence Data ; nodulation ; Nodules ; Oligonucleotide Array Sequence Analysis ; Phenotypes ; Plant cells ; Plant Growth Regulators ; Plant Growth Regulators - metabolism ; Plant Proteins ; Plant Proteins - genetics ; Plant Proteins - metabolism ; Plant Root Nodulation ; Plant Root Nodulation - genetics ; Plant roots ; Plants ; Plants, Genetically Modified ; Plants, Genetically Modified - cytology ; Plants, Genetically Modified - genetics ; Plants, Genetically Modified - growth & development ; Promoter regions ; RNA Interference ; Root growth ; root nodules ; Root Nodules, Plant ; Root Nodules, Plant - growth & development ; roots ; Sequence Analysis, DNA</subject><ispartof>Plant physiology (Bethesda), 2009-11, Vol.151 (3), p.1155-1166</ispartof><rights>Copyright 2009 American Society of Plant Biologists</rights><rights>Copyright © 2009, American Society of Plant Biologists 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-af507e4993620bbc46d752580ec8dff9d11e05736623bc7f9c45eb9119418ed73</citedby><cites>FETCH-LOGICAL-c461t-af507e4993620bbc46d752580ec8dff9d11e05736623bc7f9c45eb9119418ed73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40537943$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40537943$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19789288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuppusamy, Kavitha T</creatorcontrib><creatorcontrib>Ivashuta, Sergey</creatorcontrib><creatorcontrib>Bucciarelli, Bruna</creatorcontrib><creatorcontrib>Vance, Carroll P</creatorcontrib><creatorcontrib>Gantt, J. Stephen</creatorcontrib><creatorcontrib>VandenBosch, Kathryn A</creatorcontrib><title>Knockdown of CELL DIVISION CYCLE16 Reveals an Inverse Relationship between Lateral Root and Nodule Numbers and a Link to Auxin in Medicago truncatula</title><title>Plant physiology (Bethesda)</title><addtitle>Plant Physiol</addtitle><description>The postembryonic development of lateral roots and nodules is a highly regulated process. Recent studies suggest the existence of cross talk and interdependency in the growth of these two organs. Although plant hormones, including auxin and cytokinin, appear to be key players in coordinating this cross talk, very few genes that cross-regulate root and nodule development have been uncovered so far. This study reports that a homolog of CELL DIVISION CYCLE16 (CDC16), a core component of the Anaphase Promoting Complex, is one of the key mediators in controlling the overall number of lateral roots and nodules. A partial suppression of this gene in Medicago truncatula leads to a decrease in number of lateral roots and a 4-fold increase in number of nodules. The roots showing lowered expression of MtCDC16 also show reduced sensitivity to phytohormone auxin, thus providing a potential function of CDC16 in auxin signaling.</description><subject>Amino Acid Sequence</subject><subject>Auxins</subject><subject>biochemical pathways</subject><subject>Cell Cycle Proteins</subject><subject>Cell Cycle Proteins - genetics</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>cell morphology</subject><subject>cytology</subject><subject>Developmental biology</subject><subject>DNA, Plant</subject><subject>DNA, Plant - genetics</subject><subject>Focus Issue on Legume Biology</subject><subject>Gene expression regulation</subject><subject>Gene Expression Regulation, Plant</subject><subject>Gene Knockdown Techniques</subject><subject>gene silencing</subject><subject>gene targeting</subject><subject>genes</subject><subject>genetics</subject><subject>growth & development</subject><subject>growth and development</subject><subject>hypernodulation</subject><subject>Indoleacetic Acids</subject><subject>Indoleacetic Acids - metabolism</subject><subject>length</subject><subject>Medicago truncatula</subject><subject>Medicago truncatula - cytology</subject><subject>Medicago truncatula - genetics</subject><subject>Medicago truncatula - growth & development</subject><subject>metabolism</subject><subject>Molecular Sequence Data</subject><subject>nodulation</subject><subject>Nodules</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Phenotypes</subject><subject>Plant cells</subject><subject>Plant Growth Regulators</subject><subject>Plant Growth Regulators - metabolism</subject><subject>Plant Proteins</subject><subject>Plant Proteins - genetics</subject><subject>Plant Proteins - metabolism</subject><subject>Plant Root Nodulation</subject><subject>Plant Root Nodulation - genetics</subject><subject>Plant roots</subject><subject>Plants</subject><subject>Plants, Genetically Modified</subject><subject>Plants, Genetically Modified - cytology</subject><subject>Plants, Genetically Modified - genetics</subject><subject>Plants, Genetically Modified - growth & development</subject><subject>Promoter regions</subject><subject>RNA Interference</subject><subject>Root growth</subject><subject>root nodules</subject><subject>Root Nodules, Plant</subject><subject>Root Nodules, Plant - growth & development</subject><subject>roots</subject><subject>Sequence Analysis, DNA</subject><issn>0032-0889</issn><issn>1532-2548</issn><issn>1532-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks1u1DAUhSMEokNhyRLwClYZ_JfY3lSqwgARYSq1FImV5SQ307QZO8TOFB6E98UwowIbJEu-uufzsa-Ok-QpwUtCMH89jkuC1ZJwhim_lyxIxmhKMy7vJwuMY42lVEfJI--vMcaEEf4wOSJKSEWlXCQ_PljX3LTu1iLXoWJVVehN-bm8KM_WqPhSVCuSo3PYgRk8MhaVdgeTh9gaTOid9Vf9iGoItwAWVSbAZAZ07lyIcIvWrp0HQOt5W8dTv1sGVb29QcGh0_lbb1FcH6HtG7NxKEyzbUyYB_M4edDFG-HJYT9OLt-uPhXv0-rsXVmcVmnDcxJS02VYAFeK5RTXdWy2IqOZxNDItutUSwjgTLA8p6xuRKcankGtCFGcSGgFO05O9r7jXG-hbcCGOIAep35rpu_amV7_q9j-Sm_cTlMhGFY8Grw6GEzu6ww-6G3vGxgGY8HNXgvGCc2pJJF8-V-S55zLnOURTPdgMznvJ-junkOw_hW5HsdYKr2PPPLP_57hD33IOALP9sC1D2660znOmIgjRP3FXu-M02Yz9V5fXtD4VTDJlcx4xn4CS_q6Bg</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Kuppusamy, Kavitha T</creator><creator>Ivashuta, Sergey</creator><creator>Bucciarelli, Bruna</creator><creator>Vance, Carroll P</creator><creator>Gantt, J. Stephen</creator><creator>VandenBosch, Kathryn A</creator><general>American Society of Plant Biologists</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20091101</creationdate><title>Knockdown of CELL DIVISION CYCLE16 Reveals an Inverse Relationship between Lateral Root and Nodule Numbers and a Link to Auxin in Medicago truncatula</title><author>Kuppusamy, Kavitha T ; Ivashuta, Sergey ; Bucciarelli, Bruna ; Vance, Carroll P ; Gantt, J. Stephen ; VandenBosch, Kathryn A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-af507e4993620bbc46d752580ec8dff9d11e05736623bc7f9c45eb9119418ed73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Amino Acid Sequence</topic><topic>Auxins</topic><topic>biochemical pathways</topic><topic>Cell Cycle Proteins</topic><topic>Cell Cycle Proteins - genetics</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>cell morphology</topic><topic>cytology</topic><topic>Developmental biology</topic><topic>DNA, Plant</topic><topic>DNA, Plant - genetics</topic><topic>Focus Issue on Legume Biology</topic><topic>Gene expression regulation</topic><topic>Gene Expression Regulation, Plant</topic><topic>Gene Knockdown Techniques</topic><topic>gene silencing</topic><topic>gene targeting</topic><topic>genes</topic><topic>genetics</topic><topic>growth & development</topic><topic>growth and development</topic><topic>hypernodulation</topic><topic>Indoleacetic Acids</topic><topic>Indoleacetic Acids - metabolism</topic><topic>length</topic><topic>Medicago truncatula</topic><topic>Medicago truncatula - cytology</topic><topic>Medicago truncatula - genetics</topic><topic>Medicago truncatula - growth & development</topic><topic>metabolism</topic><topic>Molecular Sequence Data</topic><topic>nodulation</topic><topic>Nodules</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Phenotypes</topic><topic>Plant cells</topic><topic>Plant Growth Regulators</topic><topic>Plant Growth Regulators - metabolism</topic><topic>Plant Proteins</topic><topic>Plant Proteins - genetics</topic><topic>Plant Proteins - metabolism</topic><topic>Plant Root Nodulation</topic><topic>Plant Root Nodulation - genetics</topic><topic>Plant roots</topic><topic>Plants</topic><topic>Plants, Genetically Modified</topic><topic>Plants, Genetically Modified - cytology</topic><topic>Plants, Genetically Modified - genetics</topic><topic>Plants, Genetically Modified - growth & development</topic><topic>Promoter regions</topic><topic>RNA Interference</topic><topic>Root growth</topic><topic>root nodules</topic><topic>Root Nodules, Plant</topic><topic>Root Nodules, Plant - growth & development</topic><topic>roots</topic><topic>Sequence Analysis, DNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuppusamy, Kavitha T</creatorcontrib><creatorcontrib>Ivashuta, Sergey</creatorcontrib><creatorcontrib>Bucciarelli, Bruna</creatorcontrib><creatorcontrib>Vance, Carroll P</creatorcontrib><creatorcontrib>Gantt, J. Stephen</creatorcontrib><creatorcontrib>VandenBosch, Kathryn A</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Plant physiology (Bethesda)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuppusamy, Kavitha T</au><au>Ivashuta, Sergey</au><au>Bucciarelli, Bruna</au><au>Vance, Carroll P</au><au>Gantt, J. 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This study reports that a homolog of CELL DIVISION CYCLE16 (CDC16), a core component of the Anaphase Promoting Complex, is one of the key mediators in controlling the overall number of lateral roots and nodules. A partial suppression of this gene in Medicago truncatula leads to a decrease in number of lateral roots and a 4-fold increase in number of nodules. The roots showing lowered expression of MtCDC16 also show reduced sensitivity to phytohormone auxin, thus providing a potential function of CDC16 in auxin signaling.</abstract><cop>United States</cop><pub>American Society of Plant Biologists</pub><pmid>19789288</pmid><doi>10.1104/pp.109.143024</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Plant physiology (Bethesda), 2009-11, Vol.151 (3), p.1155-1166 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Amino Acid Sequence Auxins biochemical pathways Cell Cycle Proteins Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism cell morphology cytology Developmental biology DNA, Plant DNA, Plant - genetics Focus Issue on Legume Biology Gene expression regulation Gene Expression Regulation, Plant Gene Knockdown Techniques gene silencing gene targeting genes genetics growth & development growth and development hypernodulation Indoleacetic Acids Indoleacetic Acids - metabolism length Medicago truncatula Medicago truncatula - cytology Medicago truncatula - genetics Medicago truncatula - growth & development metabolism Molecular Sequence Data nodulation Nodules Oligonucleotide Array Sequence Analysis Phenotypes Plant cells Plant Growth Regulators Plant Growth Regulators - metabolism Plant Proteins Plant Proteins - genetics Plant Proteins - metabolism Plant Root Nodulation Plant Root Nodulation - genetics Plant roots Plants Plants, Genetically Modified Plants, Genetically Modified - cytology Plants, Genetically Modified - genetics Plants, Genetically Modified - growth & development Promoter regions RNA Interference Root growth root nodules Root Nodules, Plant Root Nodules, Plant - growth & development roots Sequence Analysis, DNA |
| title | Knockdown of CELL DIVISION CYCLE16 Reveals an Inverse Relationship between Lateral Root and Nodule Numbers and a Link to Auxin in Medicago truncatula |
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