OP-1 Augments Glucocorticoid-inhibited Fracture Healing in a Rat Fracture Model
Glucocorticoids inhibit bone remodeling and fracture healing. We sought to determine whether osteogenic protein 1 (OP-1) can overcome this inhibition in a closed fracture model in the rat. Time-released prednisolone or placebo pellets were implanted subcutaneously; closed femoral fractures were crea...
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| Veröffentlicht in: | Clinical orthopaedics and related research 2009-12, Vol.467 (12), p.3104-3112 |
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| creator | Gilley, Robert S. Wallace, Larry J. Bourgeault, Craig A. Kidder, Louis S. Bechtold, Joan E. |
| description | Glucocorticoids inhibit bone remodeling and fracture healing. We sought to determine whether osteogenic protein 1 (OP-1) can overcome this inhibition in a closed fracture model in the rat. Time-released prednisolone or placebo pellets were implanted subcutaneously; closed femoral fractures were created 2 weeks later in rats. Fractures received sham, OP-1 and collagen, or collagen-only implants. Femurs were harvested at 3, 10, 21, 28, and 42 days postfracture. Fractures were examined radiographically for amount of hard callus; mechanically for torque and stiffness (also expressed as a percentage of the contralateral intact femur); and histomorphometrically for amount of cartilaginous and noncartilaginous soft callus, hard callus, and total callus. Glucocorticoid administration inhibited fracture healing. The application of a devitalized Type I collagen matrix mitigated the inhibitory effects of prednisolone on fracture healing However, further increases in indices of fracture healing were observed when OP-1 was added to the collagen matrix compared with collagen alone. OP-1 and collagen was more effective than collagen alone. |
| doi_str_mv | 10.1007/s11999-009-0782-1 |
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We sought to determine whether osteogenic protein 1 (OP-1) can overcome this inhibition in a closed fracture model in the rat. Time-released prednisolone or placebo pellets were implanted subcutaneously; closed femoral fractures were created 2 weeks later in rats. Fractures received sham, OP-1 and collagen, or collagen-only implants. Femurs were harvested at 3, 10, 21, 28, and 42 days postfracture. Fractures were examined radiographically for amount of hard callus; mechanically for torque and stiffness (also expressed as a percentage of the contralateral intact femur); and histomorphometrically for amount of cartilaginous and noncartilaginous soft callus, hard callus, and total callus. Glucocorticoid administration inhibited fracture healing. The application of a devitalized Type I collagen matrix mitigated the inhibitory effects of prednisolone on fracture healing However, further increases in indices of fracture healing were observed when OP-1 was added to the collagen matrix compared with collagen alone. OP-1 and collagen was more effective than collagen alone.</description><identifier>ISSN: 0009-921X</identifier><identifier>EISSN: 1528-1132</identifier><identifier>DOI: 10.1007/s11999-009-0782-1</identifier><identifier>PMID: 19301082</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Animals ; Biomechanical Phenomena ; Bone Morphogenetic Protein 7 - administration & dosage ; Bone Remodeling - drug effects ; Bony Callus - drug effects ; Bony Callus - physiopathology ; Collagen Type I ; Conservative Orthopedics ; Disease Models, Animal ; Drug Carriers ; Drug Implants ; Femoral Fractures - diagnostic imaging ; Femoral Fractures - drug therapy ; Femoral Fractures - physiopathology ; Femur - diagnostic imaging ; Femur - drug effects ; Femur - physiopathology ; Fracture Healing - drug effects ; Glucocorticoids - administration & dosage ; Male ; Medicine ; Medicine & Public Health ; Orthopedics ; Prednisolone - administration & dosage ; Radiography ; Rats ; Sports Medicine ; Surgery ; Surgical Orthopedics ; Symposium: Tribute to Dr. Marshall Urist: Musculoskeletal Growth Factors ; Time Factors ; Torque</subject><ispartof>Clinical orthopaedics and related research, 2009-12, Vol.467 (12), p.3104-3112</ispartof><rights>The Association of Bone and Joint Surgeons 2009</rights><rights>The Association of Bone and Joint Surgeons® 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-14ba452fd8c4614f2ee38a33398a600fef26990b97ce7eeb42df08646d7336803</citedby><cites>FETCH-LOGICAL-c468t-14ba452fd8c4614f2ee38a33398a600fef26990b97ce7eeb42df08646d7336803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772924/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772924/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19301082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gilley, Robert S.</creatorcontrib><creatorcontrib>Wallace, Larry J.</creatorcontrib><creatorcontrib>Bourgeault, Craig A.</creatorcontrib><creatorcontrib>Kidder, Louis S.</creatorcontrib><creatorcontrib>Bechtold, Joan E.</creatorcontrib><title>OP-1 Augments Glucocorticoid-inhibited Fracture Healing in a Rat Fracture Model</title><title>Clinical orthopaedics and related research</title><addtitle>Clin Orthop Relat Res</addtitle><addtitle>Clin Orthop Relat Res</addtitle><description>Glucocorticoids inhibit bone remodeling and fracture healing. We sought to determine whether osteogenic protein 1 (OP-1) can overcome this inhibition in a closed fracture model in the rat. Time-released prednisolone or placebo pellets were implanted subcutaneously; closed femoral fractures were created 2 weeks later in rats. Fractures received sham, OP-1 and collagen, or collagen-only implants. Femurs were harvested at 3, 10, 21, 28, and 42 days postfracture. Fractures were examined radiographically for amount of hard callus; mechanically for torque and stiffness (also expressed as a percentage of the contralateral intact femur); and histomorphometrically for amount of cartilaginous and noncartilaginous soft callus, hard callus, and total callus. Glucocorticoid administration inhibited fracture healing. The application of a devitalized Type I collagen matrix mitigated the inhibitory effects of prednisolone on fracture healing However, further increases in indices of fracture healing were observed when OP-1 was added to the collagen matrix compared with collagen alone. 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We sought to determine whether osteogenic protein 1 (OP-1) can overcome this inhibition in a closed fracture model in the rat. Time-released prednisolone or placebo pellets were implanted subcutaneously; closed femoral fractures were created 2 weeks later in rats. Fractures received sham, OP-1 and collagen, or collagen-only implants. Femurs were harvested at 3, 10, 21, 28, and 42 days postfracture. Fractures were examined radiographically for amount of hard callus; mechanically for torque and stiffness (also expressed as a percentage of the contralateral intact femur); and histomorphometrically for amount of cartilaginous and noncartilaginous soft callus, hard callus, and total callus. Glucocorticoid administration inhibited fracture healing. The application of a devitalized Type I collagen matrix mitigated the inhibitory effects of prednisolone on fracture healing However, further increases in indices of fracture healing were observed when OP-1 was added to the collagen matrix compared with collagen alone. OP-1 and collagen was more effective than collagen alone.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>19301082</pmid><doi>10.1007/s11999-009-0782-1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Biomechanical Phenomena Bone Morphogenetic Protein 7 - administration & dosage Bone Remodeling - drug effects Bony Callus - drug effects Bony Callus - physiopathology Collagen Type I Conservative Orthopedics Disease Models, Animal Drug Carriers Drug Implants Femoral Fractures - diagnostic imaging Femoral Fractures - drug therapy Femoral Fractures - physiopathology Femur - diagnostic imaging Femur - drug effects Femur - physiopathology Fracture Healing - drug effects Glucocorticoids - administration & dosage Male Medicine Medicine & Public Health Orthopedics Prednisolone - administration & dosage Radiography Rats Sports Medicine Surgery Surgical Orthopedics Symposium: Tribute to Dr. Marshall Urist: Musculoskeletal Growth Factors Time Factors Torque |
| title | OP-1 Augments Glucocorticoid-inhibited Fracture Healing in a Rat Fracture Model |
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