NMR Strategy for Unraveling Structures of Bioactive Sponge-Derived Oxy-polyhalogenated Diphenyl Ethers

The overexpression of the Mcl-1 protein in cancerous cells results in the sequestering of Bak, a key component in the regulation of normal cell apoptosis. Our investigation of the ability of marine-derived small-molecule natural products to inhibit this protein−protein interaction led to the isolati...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2009-03, Vol.72 (3), p.443-449
Hauptverfasser:	Calcul, Laurent, Chow, Raymond, Oliver, Allen G, Tenney, Karen, White, Kimberly N, Wood, Alexander W, Fiorilla, Catherine, Crews, Phillip
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Crystallography, X-Ray Drug Screening Assays, Antitumor Dysidea - chemistry General pharmacology Halogenated Diphenyl Ethers - chemistry Halogenated Diphenyl Ethers - isolation & purification Halogenated Diphenyl Ethers - pharmacology Medical sciences Molecular Conformation Molecular Structure Myeloid Cell Leukemia Sequence 1 Protein Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - drug effects Proto-Oncogene Proteins c-bcl-2 - metabolism
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